Research Publications

Faculty Research Publications
  • Hassan Venkatesh G*, Abou Khouzam R*,  Elsayed WSM, Zeinelabdin NA, Terry S, Chouaib S. Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity? OncoImmunology. 2021 Sep 27. [View Abstract]
  • Lakshmanan VK, Jindal S, Packirisamy G, Ojha S, Lian S, Kaushik A, Alzarooni AIMA, Metwally YAF, Thyagarajan SP, Do Jung Y, Chouaib S.Nanomedicine-based cancer immunotherapy: recent trends and future perspectives. Cancer Gene Ther. 2021 Sep. [View Abstract]
  • Chamseddine AN, Assi T, Mir O, Chouaib S. Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach. Pharmacol Ther. 2021 Sep 2. [View Abstract]
  • Ziani L, Buart S, Chouaib S, Thiery J. Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity. Oncoimmunology. 2021 Jul 25. [View Abstract]
  • Buart S, Terry S, Diop MK, Dessen P, Couvé S, Abdou A, Adam J, Thiery J, Savagner P, Chouaib S. The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation. Cancers (Basel). 2021 Aug 2. [View Abstract]
  • Folmont D A, Bourhis HJ, Chouaib S, Terry S Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy immuno 25 June 2021. [View Abstract]
  • Terry S, Dalban C, Rioux Leclercq N, Adam J, Meylan M, Buart S, Bougoüin A, Lespagnol A, Dugay F, Colina Moreno I, Lacroix G, Lorens JB, Gausdal G, Fridman WH, Mami-Chouaib F, Chaput N, Beuselinck B, Chabaud S, Barros Monteiro J, Vano Y, Escudier B, Sautes-Fridman C, Albiges L, Chouaib S. Association of AXL and PD-L1 expression with clinical outcomes in patients with advanced renal cell carcinoma treated with PD-1 blockade. Clin Cancer Res. 2021 Aug 18. [View Abstract]
  • Venkatesh G.H. (2021) Hypoxic Stress Perturb DNA Repair Mechanisms Leading to Genetic Instability. In: Chakraborti S., Ray B.K., Roychowdhury S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. [View Abstract]
  • Lequeux A, Noman MZ, Xiao M, Van Moer K, Hasmim M, Benoit A, Bosseler M, Viry E, Arakelian T, Berchem G, Chouaib S, Janji B. Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy. Oncogene. 2021 Jul;40(28):4725-4735. [View Abstract]
  • Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, Kieda C, Olive D, Chouaib S. Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep. 2021 Feb;45(2):582-594. [View Abstract]
  • Algehani RA, Abou Khouzam R, Gehan A. Hegazyb GA, Alamoudi AA,El-Halawany AM, Eldine RS, Ajabnoor GA, Al-Abbasi FA, Baghdadii MA, Elsayed I, Hattori M, Al-Abd AM. Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells. Biomedicine & Pharmacotherapy 2021.
  • Abou Khouzam R, Prasad Rao RS, Venkatesh GH, Zeinelabdin NA, Buart S, Meylan M, Nimmakayalu M, Terry S and Chouaib S. An eight-gene hypoxia signature predicts survival in pancreatic cancer and is associated with an immunosuppressed tumor microenvironment. Frontiers in Immunology 2021  doi: 10.3389/fimmu.2021.680435. [View Abstract]
  • Zaarour RF, Azakir B, Hajam EY, Nawafleh H, Zeinelabdin NA, Engelsen AST, Thiery J, Jamora C and Chouaib S. Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival Cancers 2021, 13(3), 533; [View Abstract]
  • Zaarour RF, Prasad P,Venkatesh GH, Abou Khouzam R, Amirtharaj F, Zeinelabdin N,  RIFATH A, Terry S, Nawafleh H, El Sayed Y and Chouaib S. Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell linesOncology Reports, January 2021. [View Abstract]
  • Abou Khouzam R, Brodaczewska K, Filipiak A, Zeinelabdin N, Buart S, Szczylik C, Kieda C, Chouaib S.  Tumor hypoxia regulates immune escape / invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies. Frontiers in Immunology. 20 January 2021. [View Abstract]
  • Lotsberg ML, Rayford A, Thiery JP, Belleggia G, Peters SD, Lorens JB, Couaib S, Terry S, Engelsen AST. Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockadeCancer Drug Resistance. September 2020. [View_Abstract]
  • Lakshmanan VK, Jindal S, Gopinath P, Chouaib S, Nanomedicine based Cancer Immunotherapy: Recent Trends and Future Perspectives. Nature Cancer Gene Therapy. Sept 2020.
  • Elbehairi, S. E. I., Ezzat Ahmed, A., Alshati, A. A., Al-Kahtani, M. A., Alfaifi, M. Y., Alsyaad, K. M., Alalmie, A. Y. A. ., Elimam Ahamed, M. M., Moustafa, M. F., Alhag, S. K., Al-Abd, A. M., & Abbas, A. M. (2020). Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell linesEXCLI Journal, 19, 1282-1294. [View Abstract]
  • Henidi, H., Al-Abbasi, F., El-Moselhy, M., El-Bassossy, H., & Al-Abd, A. (2020). Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer ActivityOxidative Medicine And Cellular Longevity2020, 1-14. doi: 10.1155/2020/8157640. [View Abstract]
  • Terry S, Engelsen AST, Buart S, Elsayed WS, Venkatesh GH, Chouaib S. Hypoxia-driven intratumor heterogeneity and immune evasion. Cancer Lett. 2020 Jul 23:S0304-3835(20)30359-1. [View Abstract]
  • Bawadood ASAl-Abbasi FAAnwar F El-Halawany AM Al-Abd AM. 6-Shogaol Suppresses the Growth of Breast Cancer Cells by Inducing Apoptosis and Suppressing Autophagy via Targeting Notch Signaling PathwayBiomed Pharmacother2020 Jun 4;128:110302. [View Abstract]
  • Yehia El Batawi H, Venkatachalam T, Francis A, Abujabal R, Al Shehadat S. Dental Caries-A Hiding Niche for Helicobacter Pylori in Children. J Clin Pediatr Dent. 2020;44(2):90-94. [View Abstract]
  • Salem Chouaib. The Antitumor Cytotoxic Response: If the Killer Cells Play the Music, the Microenvironmental Hypoxia Plays the Tune. Crit Rev Immunol. 2020;40(2): 157-166. DOI: 10.1615/CritRevImmunol.2020033492. [View Abstract]
  • Salem Chouaib and James Lorens. Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy. Frontiers in immunology. 15 May 2020. [View Abstract]
  • Venkatesh GH, Bravo P , Elsayed W, Amirtharaj F, Wojtas B, Abou Khouzam R,  Nawafleh HH , Mallya S ,  Satyamoorthy K,  Dessen P,  Rosselli F,  Thiery J , Chouaib S. Hypoxia Increases Mutational Load of Breast Cancer Cells Through Frameshift MutationsOncoimmunology. 2020 Apr 16;9(1):1750750. doi: 10.1080/2162402X.2020.1750750. [View Abstract]
  • Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr OK, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug resistant cancer cellsJ Thorac Oncol. 2020 Feb 1. pii: S1556-0864(20)30055-1. doi: 10.1016/j.jtho.2020.01.015. [View Abstract]
  • Khouzam RA, Goutham HV, Zaarour RF, Chamseddine AN, Francis A, Buart S, Terry S, Chouaib S. Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapySemin Cancer Biol. 2020 Jan 9. pii: S1044-579X(20)30004-3. doi: 10.1016/j.semcancer.2020.01.003. [View Abstract]
  • Otandault A, Abraham JD, Al Amir Dache Z, Khalyfa A, Jariel-Encontre I, Forné T, Prévostel C, Chouaib S, Gozal D, Thierry AR. Hypoxia differently modulates the release of mitochondrial and nuclear DNABr J Cancer. 2020 Jan 13. doi: 10.1038/s41416-019-0716-y. [View Abstract]
  • Shetty PJ, Amirtharaj F, Shaik NA (2019). Introduction to Nucleic acid Sequencing. Essentials of Bioinformatics: Genes to Proteins. 1(1):97-126. [View Abstract]
  • Terry S, Abdou A, Engelsen AST, Buart S, Dessen P, Corgnac S, Collares D, Meurice G, Gausdal G, Baud V, Saintigny P, Lorens JB, Thiery J-P, Mami-Chouaib F, Chouaib S. AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity. Cancer Immunol Res. 2019;7(11):1789–802. [View Abstract]
  • Chollat-Namy M, Ben Safta-Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagyCell Death Dis. 2019 Sep 20;10(10):695. [View Abstract]
  • Noman MZ, Hasmim M, Lequeux A, Xiao M, Duhem C, Chouaib S, et al. Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges. Cells. 2019 Sep 14;8(9):1083. [View Abstract]
  • Francis A, Venkatesh GH, Zaarour RF, Zeinelabdin NA, Nawafleh HH, Prasad P, et al. Tumor Hypoxia: A Key Determinant of Microenvironment Hostility and a Major Checkpoint during the Antitumor Response. Crit Rev Immunol. 2018;38(6):505–24. [View Abstract]
  • Durgeau A, Virk Y, Gros G, Voilin E, Corgnac S, Djenidi F, et al. Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours. Nat Commun. 2018 Dec 30;9(1):5097. [View Abstract]
  • Terry S, Faouzi ZR, Hassan VG, Francis A, El-Sayed W, Buart S, Bravo P, Thiery J, Chouaib S. Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity. Int J Mol Sci. 2018 Oct 6;19(10):3044. [View Abstract]
  • Al Absi A, Wurzer H, Guerin C, Hoffmann C, Moreau F, Mao X, Brown-Clay J, Petrolli R, Casellas CP, Dieterle M, Thiery JP, Chouaib S, Berchem G, Janji B, Thomas C. Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity. Cancer Res. 2018 Oct 1;78(19):5631-5643. [View Abstract]
  • Janji B, Berchem G, Chouaib S. Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity. Front Immunol. 2018 Apr 25;9:887. doi: 10.3389/fimmu.2018.00887. [View Abstract]
  • Foucher ED, Ghigo C, Chouaib S, Galon J, Iovanna J, Olive D. Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment. Front Immunol. 2018 May 14;9:1044. [View Abstract]
  • Chouaib S, Umansky V, Kieda C. The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment. Contemp Oncol (Pozn). 2018 Mar;22(1A):7-13. [View Abstract]