Research Publications

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Faculty Research Publications
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2024

  • Kapoor S, Mihalovičová L, Pisareva E, Pastor B, Mirandola A, Roch B, Bryant J, Princy AP, Chouaib S, Thierry AR. Association of vascular netosis with COVID-19 severity in asymptomatic and symptomatic patients. iScience. 2024 Mar 26. [link]
  • Zirmire R.K., Saha D., Dey R., Tanimu H., Zaarour R., Bird D., Cherian P., Rana I., Roy N., Sanyal A., Misra N., Jamora C. Bacopa monnieri phytochemicals regulate fibroblast cell migration via modulation of focal adhesions. March 2024 iScience. [link]

2023

  1. Buart S, Diop MK, Damei I, Chouaib S. Sunitinib Treatment of VHL C162F Cells Slows Down Proliferation and Healing Ability via Downregulation of ZHX2 and Confers a Mesenchymal Phenotype. Cancers (Basel). 2023 Dec 20. [link]
  2. Said M, Elsayed I, Aboelwafa AA, Elshafeey AH, Hassan M. Ocular mucoadhesive and biodegradable sponge-like inserts for the sustained and controlled delivery of voriconazole; preparation, D-optimal factorial optimization and in-vivo evaluation. J Pharm Sci. 2023 Nov 8. [link]
  3. Zaarour RF, Ribeiro M, Azzarone B, Kapoor S, Chouaib S. Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance. Front Oncol. 2023 Oct 11. [link]
  4. Abou Khouzam R, Janji B, Thiery J, Zaarour RF, Chamseddined AN, Mayre H, Savagner P, Kieda C, Gad S, Buart S, Lehn JM, Limani P, Chouaib S. Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy. Semin Cancer Biol. 2023. 97:104-123. doi: 10.1016/j.semcancer.2023.11.008
  5. Iqbal MA, Siddiqui S, Smith K, Singh P, Kumar B, Chouaib S, and Chandrasekaran S. Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance, iScience, 2023. [link]
  6. Odeh HI, Al-Badi SR, Karima B, Saeed TA, Rahamathullah N, Ibrahim EH, Ismail MK, Arshad Khan Z. Exploring the prevalence of Human Papillomavirus (HPV) genotypes in PAP smear samples of women in northern region of United Arab Emirates (UAE): HPV Direct Flow CHIP system-based pilot study. PLoS One. 2023 Sep 6;18(9):e0286889. [link]
  7. Kyerewah- Kersi SM, Khan E, Goutham HV, Abou Khouzam R. “Hypoxia is associated with increased expression of APOBEC genes in breast cancer”. Hamdan Medical Journal. June 2023. 16:94-100. [link]
  8. Di Matteo S, Munari E, Fiore PF, Santopolo S, Sampaoli C, Pelosi A, Chouaib S, Tumino N, Vacca P, Mariotti FR, Ebert S, Machwirth M, Haas D, Pezzullo M, Pietra G, Grottoli M, Buart S, Mortier E, Maggi E, Moretta L, Caruana I, Azzarone B. The roles of different forms of IL-15 in human melanoma progression. Front Immunol. 2023 Jun 2;14:1183668. [link]
  9. Abou Khouzam R, Goutham HV, Rao SP, Chouaib S. A prognostic hypoxia gene signature is associated with a dampened tumour immune microenvironment in cervical cancer. Hamdan Medical Journal. March 2023. 16: 7-13. [link]
  10. Abou Khouzam R, Sharda M, Shyama Prasad R, Kyerewah- Kersi SM, Zeinelabdin NA, Mahmood AS, Nawafleh H, Khan MS, Venkatesh GH and Chouaib S. Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells. Front. Cell Dev. Biol. Sec. Cancer Cell Biology.  2023; 11: 1095419. [link]
  11. Ramesh S, Selvakumar P, Ameer MY, Lian S, Abdullah Alzarooni AIM, Ojha S, Mishra A, Tiwari A, Kaushik A, Jung YD, Chouaib S, Lakshmanan VK. State-of-the-art therapeutic strategies for targeting cancer stem cells in prostate cancer. Front Oncol. 2023 Mar 9;13:1059441. [link]
  12. Abou Khouzam R, Lehn JM, Mayr  H, Clavien PA, Wallace MB, Ducreux M, Limani P and Chouaib S. Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy. Cancers. 15(4), 1235; [link]

2022

  1. Rana I, Kataria S, Tan TL, Hajam EY, Kashyap DK, Saha D, Ajnabi J, Paul S, Jayappa S, Ananthan ASHP, Kumar P, Zaarour RF, Haarshaadri J, Samuel R, George R, Danda D, Jacob PM, Dey R, Perundurai D, He YW, Varga J, Varghese S, Jamora C. Mindin is essential for cutaneous fibrogenesis in a new mouse model of systemic sclerosis Journal of Investigative Dermatology 2022 October. [View Abstract]
  2. Mortara L, Benest AV,  Derosa L, Chouaib S, Ribatti  D. The intricate innate immune-cancer cell relationship in the context of tumor angiogenesis, immunity and microbiota: The angiogenic switch in the tumor microenvironment as a key target for immunotherapies. Frontiers. [View Abstract]
  3. Doffe F, Bonini F, Lakis E, Terry S, Chouaib S, Savagner P. Designing Organoid Models to Monitor Cancer Progression, Plasticity and Resistance: The Right Set Up for the Right Question. Cancers (Basel). 2022 Jul 22. [View Abstract]
  4. Zaarour RF, Sharda M, Azakir B, Venkatesh GH, Abou Khouzam R, Rifath A, Nizami ZN, Abdullah F, Mohammad F, Karaali H, Nawafleh H, Elsayed Y and Chouaib S. Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity. International Journal of Molecular Sciences 2022, 23(12), 6848. [View Abstract]
  5. Janji B, Chouaib S. The Promise of Targeting Hypoxia to Improve Cancer Immunotherapy: Mirage or Reality? Frontiers in Immunology. 20 June 2022. [View Abstract]
  6. Carril-Ajuria L, Desnoyer A, Meylan M, Dalban C, Naigeon M, Cassard L, Vano Y, Rioux-Leclercq N, Chouaib S, Beuselinck B, Chabaud S, Barros-Monteiro J, Bougoüin A, Lacroix G, Colina-Moreno I, Tantot F, Boselli L, De Oliveira C, Fridman WH, Escudier B, Sautes-Fridman C, Albiges L, Chaput-Gras N. Baseline circulating unswitched memory B cells and B-cell related soluble factors are associated with overall survival in patients with clear cell renal cell carcinoma treated with nivolumab within the NIVOREN GETUG-AFU 26 study. J Immunother Cancer. 2022 May. [View Abstract]
  7. Corgnac S, Damei I, Gros G, Caidi A, Terry S, Chouaib S, Deloger M, Mami-Chouaib F. Cancer stem-like cells evade CD8+CD103+ tumor-resident memory T (TRM) lymphocytes by initiating an epithelial-to-mesenchymal transition program in a human lung tumor model. Journal of Immunotherapy of Cancer. 2022 Apr;10. [View Abstract]
  8. Chamseddine AN, Assi T, Mir O, Chouaib S. Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach. Pharmacology and Therapeutics 2022 Mar. [View Abstract]
  9. Zaarour RF, Saha D, Dey R, Dutta A, Kumar P, Rana I, Pulianmackal A, Rizvi A, Misra N, Breton L, Jamora C. The neuropeptide Substance P facilitates the transition from an inflammatory to proliferation phase-associated responses in dermal fibroblasts. Experimental Dermatology 30 March 2022. [View Abstract]
  10. Engelsen AST, Lotsberg ML, Abou Khouzam R, Thiery J-P, Lorens JB, Chouaib S, Terry S. Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition. Frontiers in Immunology 16 March 2022. [View Abstract]
  11. Abou Khouzam R, Zaarour RF, Brodaczewska K, Azakir B, Goutham HV, Thiery J, Terry S, Chouaib S. The effect of hypoxia and hypoxia-associated pathways in the regulation of antitumor response: friends or foes? Frontiers in Immunology 08 February 2022. [View Abstract]
  12. Amirtharaj F, Venkatesh G, Wojtas B, Nawafleh H, Mahmood A, Nizami Z, Khan M, Thiery J, Chouaib S. PRIMA-1MET/APR-246, a p53 reactivating small molecule regulates genomic instability in MDA-MB-231 cell line. Oncology reports 2022 Jan 12. [View Abstract]

2021

  1. Chouaib S., Hypoxia as a Potential Inducer of Immune Tolerance and a Driver of Tumor Mutational Burden: Impact on Cancer Immunotherapy. Onco Therapeutics, 8(1):1 – 9 (2021).
  2. Hassan Venkatesh G*, Abou Khouzam R*,  Elsayed WSM, Zeinelabdin NA, Terry S, Chouaib S. Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity? OncoImmunology. 2021 Sep 27. [View Abstract]
  3. Lakshmanan VK, Jindal S, Packirisamy G, Ojha S, Lian S, Kaushik A, Alzarooni AIMA, Metwally YAF, Thyagarajan SP, Do Jung Y, Chouaib S.Nanomedicine-based cancer immunotherapy: recent trends and future perspectives. Cancer Gene Ther. 2021 Sep. [View Abstract]
  4. Ziani L, Buart S, Chouaib S, Thiery J. Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity. Oncoimmunology. 2021 Jul 25. [View Abstract]
  5. Buart S, Terry S, Diop MK, Dessen P, Couvé S, Abdou A, Adam J, Thiery J, Savagner P, Chouaib S. The Most Common VHL Point Mutation R167Q in Hereditary VHL Disease Interferes with Cell Plasticity Regulation. Cancers (Basel). 2021 Aug 2. [View Abstract]
  6. Folmont D A, Bourhis HJ, Chouaib S, Terry S Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy immuno 25 June 2021. [View Abstract]
  7. Terry S, Dalban C, Rioux Leclercq N, Adam J, Meylan M, Buart S, Bougoüin A, Lespagnol A, Dugay F, Colina Moreno I, Lacroix G, Lorens JB, Gausdal G, Fridman WH, Mami-Chouaib F, Chaput N, Beuselinck B, Chabaud S, Barros Monteiro J, Vano Y, Escudier B, Sautes-Fridman C, Albiges L, Chouaib S. Association of AXL and PD-L1 expression with clinical outcomes in patients with advanced renal cell carcinoma treated with PD-1 blockade. Clin Cancer Res. 2021 Aug 18. [View Abstract]
  8. Venkatesh G.H. (2021) Hypoxic Stress Perturb DNA Repair Mechanisms Leading to Genetic Instability. In: Chakraborti S., Ray B.K., Roychowdhury S. (eds) Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Springer, Singapore. [View Abstract]
  9. Lequeux A, Noman MZ, Xiao M, Van Moer K, Hasmim M, Benoit A, Bosseler M, Viry E, Arakelian T, Berchem G, Chouaib S, Janji B. Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy. Oncogene. 2021 Jul;40(28):4725-4735. [View Abstract]
  10. Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, Kieda C, Olive D, Chouaib S. Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep. 2021 Feb;45(2):582-594. [View Abstract]
  11. Algehani RA, Abou Khouzam R, Gehan A. Hegazyb GA, Alamoudi AA,El-Halawany AM, Eldine RS, Ajabnoor GA, Al-Abbasi FA, Baghdadii MA, Elsayed I, Hattori M, Al-Abd AM. Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells. Biomedicine & Pharmacotherapy 2021.
  12. Abou Khouzam R, Prasad Rao RS, Venkatesh GH, Zeinelabdin NA, Buart S, Meylan M, Nimmakayalu M, Terry S and Chouaib S. An eight-gene hypoxia signature predicts survival in pancreatic cancer and is associated with an immunosuppressed tumor microenvironment. Frontiers in Immunology 2021  doi: 10.3389/fimmu.2021.680435. [View Abstract]
  13. Zaarour RF, Azakir B, Hajam EY, Nawafleh H, Zeinelabdin NA, Engelsen AST, Thiery J, Jamora C and Chouaib S. Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival Cancers 2021, 13(3), 533; [View Abstract]
  14. Zaarour RF, Prasad P,Venkatesh GH, Abou Khouzam R, Amirtharaj F, Zeinelabdin N,  RIFATH A, Terry S, Nawafleh H, El Sayed Y and Chouaib S. Waterpipe smoke condensate influences epithelial to mesenchymal transition and interferes with the cytotoxic immune response in non-small cell lung cancer cell lines. Oncology Reports, January 2021. [View Abstract]
  15. Abou Khouzam R, Brodaczewska K, Filipiak A, Zeinelabdin N, Buart S, Szczylik C, Kieda C, Chouaib S.  Tumor hypoxia regulates immune escape / invasion: influence on angiogenesis and potential impact of hypoxic biomarkers on cancer therapies. Frontiers in Immunology. 20 January 2021. [View Abstract]

2020

  1. Lotsberg ML, Rayford A, Thiery JP, Belleggia G, Peters SD, Lorens JB, Couaib S, Terry S, Engelsen AST. Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade. Cancer Drug Resistance. September 2020. [View_Abstract]
  2. Elbehairi, S. E. I., Ezzat Ahmed, A., Alshati, A. A., Al-Kahtani, M. A., Alfaifi, M. Y., Alsyaad, K. M., Alalmie, A. Y. A. ., Elimam Ahamed, M. M., Moustafa, M. F., Alhag, S. K., Al-Abd, A. M., & Abbas, A. M. (2020). Prosopis juliflora leave extracts induce cell death of MCF-7, HepG2, and LS-174T cancer cell lines. EXCLI Journal, 19, 1282-1294. [View Abstract]
  3. Henidi, H., Al-Abbasi, F., El-Moselhy, M., El-Bassossy, H., & Al-Abd, A. (2020). Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity. Oxidative Medicine And Cellular Longevity, 2020, 1-14. doi: 10.1155/2020/8157640. [View Abstract]
  4. Terry S, Engelsen AST, Buart S, Elsayed WS, Venkatesh GH, Chouaib S. Hypoxia-driven intratumor heterogeneity and immune evasion. Cancer Lett. 2020 Jul 23:S0304-3835(20)30359-1. [View Abstract]
  5. Bawadood AS, Al-Abbasi FA, Anwar F , El-Halawany AM , Al-Abd AM. 6-Shogaol Suppresses the Growth of Breast Cancer Cells by Inducing Apoptosis and Suppressing Autophagy via Targeting Notch Signaling Pathway. Biomed Pharmacother. 2020 Jun 4;128:110302. [View Abstract]
  6. Yehia El Batawi H, Venkatachalam T, Francis A, Abujabal R, Al Shehadat S. Dental Caries-A Hiding Niche for Helicobacter Pylori in Children. J Clin Pediatr Dent. 2020;44(2):90-94. [View Abstract]
  7. Salem Chouaib. The Antitumor Cytotoxic Response: If the Killer Cells Play the Music, the Microenvironmental Hypoxia Plays the Tune. Crit Rev Immunol. 2020;40(2): 157-166. DOI: 10.1615/CritRevImmunol.2020033492. [View Abstract]
  8. Salem Chouaib and James Lorens. Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy. Frontiers in immunology. 15 May 2020. [View Abstract]
  9. Venkatesh GH, Bravo P , Elsayed W, Amirtharaj F, Wojtas B, Abou Khouzam R,  Nawafleh HH , Mallya S ,  Satyamoorthy K,  Dessen P,  Rosselli F,  Thiery J , Chouaib S. Hypoxia Increases Mutational Load of Breast Cancer Cells Through Frameshift Mutations. Oncoimmunology. 2020 Apr 16;9(1):1750750. doi: 10.1080/2162402X.2020.1750750. [View Abstract]
  10. Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr OK, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. AXL targeting abrogates autophagic flux and induces immunogenic cell death in drug resistant cancer cells. J Thorac Oncol. 2020 Feb 1. pii: S1556-0864(20)30055-1. doi: 10.1016/j.jtho.2020.01.015. [View Abstract]
  11. Khouzam RA, Goutham HV, Zaarour RF, Chamseddine AN, Francis A, Buart S, Terry S, Chouaib S. Integrating tumor hypoxic stress in novel and more adaptable strategies for cancer immunotherapy. Semin Cancer Biol. 2020 Jan 9. pii: S1044-579X(20)30004-3. doi: 10.1016/j.semcancer.2020.01.003. [View Abstract]
  12. Otandault A, Abraham JD, Al Amir Dache Z, Khalyfa A, Jariel-Encontre I, Forné T, Prévostel C, Chouaib S, Gozal D, Thierry AR. Hypoxia differently modulates the release of mitochondrial and nuclear DNA. Br J Cancer. 2020 Jan 13. doi: 10.1038/s41416-019-0716-y. [View Abstract]

2019

  1. Shetty PJ, Amirtharaj F, Shaik NA (2019). Introduction to Nucleic acid Sequencing. Essentials of Bioinformatics: Genes to Proteins. 1(1):97-126. [View Abstract]
  2. Terry S, Abdou A, Engelsen AST, Buart S, Dessen P, Corgnac S, Collares D, Meurice G, Gausdal G, Baud V, Saintigny P, Lorens JB, Thiery J-P, Mami-Chouaib F, Chouaib S. AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity. Cancer Immunol Res. 2019;7(11):1789–802. [View Abstract]
  3. Chollat-Namy M, Ben Safta-Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019 Sep 20;10(10):695. [View Abstract]
  4. Noman MZ, Hasmim M, Lequeux A, Xiao M, Duhem C, Chouaib S, et al. Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges. Cells. 2019 Sep 14;8(9):1083. [View Abstract]

2018

  1. Francis A, Venkatesh GH, Zaarour RF, Zeinelabdin NA, Nawafleh HH, Prasad P, et al. Tumor Hypoxia: A Key Determinant of Microenvironment Hostility and a Major Checkpoint during the Antitumor Response. Crit Rev Immunol. 2018;38(6):505–24. [View Abstract]
  2. Durgeau A, Virk Y, Gros G, Voilin E, Corgnac S, Djenidi F, et al. Human preprocalcitonin self-antigen generates TAP-dependent and -independent epitopes triggering optimised T-cell responses toward immune-escaped tumours. Nat Commun. 2018 Dec 30;9(1):5097. [View Abstract]
  3. Terry S, Faouzi ZR, Hassan VG, Francis A, El-Sayed W, Buart S, Bravo P, Thiery J, Chouaib S. Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity. Int J Mol Sci. 2018 Oct 6;19(10):3044. [View Abstract]
  4. Al Absi A, Wurzer H, Guerin C, Hoffmann C, Moreau F, Mao X, Brown-Clay J, Petrolli R, Casellas CP, Dieterle M, Thiery JP, Chouaib S, Berchem G, Janji B, Thomas C. Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity. Cancer Res. 2018 Oct 1;78(19):5631-5643. [View Abstract]
  5. Janji B, Berchem G, Chouaib S. Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity. Front Immunol. 2018 Apr 25;9:887. doi: 10.3389/fimmu.2018.00887. [View Abstract]
  6. Foucher ED, Ghigo C, Chouaib S, Galon J, Iovanna J, Olive D. Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment. Front Immunol. 2018 May 14;9:1044. [View Abstract]
  7. Chouaib S, Umansky V, Kieda C. The role of hypoxia in shaping the recruitment of proangiogenic and immunosuppressive cells in the tumor microenvironment. Contemp Oncol (Pozn). 2018 Mar;22(1A):7-13. [View Abstract]

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