Dr. Muhammed Abdullatif

Gulf Medical University > Dr. Muhammed Abdullatif
gmu

Associate Professor of Pharmacology & Toxicology

Education

  • Ph.D. in Pharmacology and Toxicology from Cairo University, Egypt in 2015
  • MSc in Pharmacology and Toxicology from Cairo University, Egypt in 2012
  • B.Pharm from Cairo University, Egypt in 2005

Research interests

  • Central nervous System: Cerebral ischemia, Dementia, Depression, Multiples Sclerosis, Huntington’s Chorea
  • Sexual disorders.
  • Inflammatory disorders.

Selected Publications

  • Al-Madhagy, S. A., Gad, S. S., Mostafa, E. S., Angeloni, S., Saad, M. A., Sabry, O. M., Caprioli, G., & El-Hawary, S. S. (2023). A new firewall in the fight against breast cancer: in-vitro and in-silico studies correlating chemistry to apoptotic activity of Otostegia fruticosa. Natural product research, 37(16), 2770–2775. [link]
  • Khaled, A.,  Ahmed, E.,  Mamdouh, M.,  Saad, H.,  Mohamed, A.,  Sobhy, M.,  Piatti, D.,  Sabry, M.,  Saad, M. A., Sabry, O. M., &  Caprioli, G. (2023).  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases. Phytotherapy Research, 1–9. [link]
  • Arab, H. H., Eid, A. H., Yahia, R., Alsufyani, S. E., Ashour, A. M., El-Sheikh, A. A. K., Darwish, H. W., Saad, M. A., Al-Shorbagy, M. Y., & Masoud, M. A. (2023). Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats. Pharmaceuticals, 16(9), 1214. [link]
  • Arab, H. H., Fikry, E. M., Alsufyani, S. E., Ashour, A. M., El-Sheikh, A. A. K., Darwish, H. W., Al-Hossaini, A. M., Saad, M. A., Al-Shorbagy, M. Y., & Eid, A. H. (2023). Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways. Pharmaceuticals, 16(7), 1006. [link]
  • Zaki, E. S., Sayed, R. H., Saad, M. A., & El-Yamany, M. F. (2023). Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway. Life Sciences, 327, 121806. [link]
  • Kamel, A. S., Farrag, S. M., Mansour, H. M., Nassar, N. N., & Saad, M. A. (2023). Dapagliflozin modulates neuronal injury via instigation of LKB1/p-AMPK/GABA B R2 signaling pathway and suppression of the inflammatory cascade in an essential tremor rat model. Expert Opinion on Therapeutic Targets. [link]
  • Darwish, A. B., El Sayed, N. S., Salama, A. A. A., & Saad, M.A.E. (2023). Dulaglutide impedes depressive-like behavior persuaded by chronic social defeat stress model in male C57BL/6 mice: Implications on GLP-1R and cAMP/PKA signaling pathway in the hippocampus. Life sciences, 320, 121546. [link]
  • Khedr, L.H., Eladawy, R.M., Nassar, N.N., Saad, M.A.E. Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling. Neuropharmacology. 2023 Feb 1;223:109293. doi: 10.1016/j.neuropharm.2022.109293. Epub 2022 Oct 19. PMID: 36272443.
  • Khedr, L.H., Eladawy, R.M., Nassar, N.N., & Saad, M.A. (2022). Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling. Neuropharmacology, 109293. [link]
  • Al-Madhagy, S., Gad, S., Mostafa, E., Angeloni, S., Saad, M.A., & Sabry, O. et al. (2022). A new firewall in the fight against breast cancer: in-vitro and in-silico studies correlating chemistry to apoptotic activity of Otostegia fruticosa. Natural Product Research, 1-6. doi: 10.1080/14786419.2022.2130306. [link]
  • Mohammed, R., Sayed, R., El-Sahar, A., Khattab, M., & Saad, M.A. (2022). Insights into the role of pERK1/2 signaling in post-cerebral ischemia reperfusion sexual dysfunction in rats. European Journal Of Pharmacology, 933, 175258. doi: 10.1016/j.ejphar.2022.175258. [link]
  • Saad, M.A, Eissa, N., Ahmed, M., ElMeshad, A., Laible, G., Attia, A., Al-Ghobashy, M.A., Abdelsalam, R.M., Al-Shorbagy, M.Y. (2022). Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice. International Journal Of Nanomedicine, Volume 17, 3967-3987. doi: 10.2147/ijn.s359114. [link]
  • Targeting the TLR4/NF-kB Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-induced Cognitive Decline Neuropathology in Rats. Muhammed A. Saad, Muhammad Y Al-Shorbagy, Hany H Arab. Molecular Neurobiology – 2022. Epub Ahead of print. [link]
  • Inosine attenuates 3-nitropropionic acid-induced Huntington’s disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway. Marwa El-Sayed El-Shamarka, Ayman E. El-Sahar, Muhammed A. Saad, Naglaa Assaf, Rabab H. Sayed. Life Sciences – 2022. Epub Ahead of print. [link]
  • A new arsenal of polyphenols to make Parkinson’s disease extinct: HPLC-MS/MS profiling, very interesting MAO-B inhibitory activity and antioxidant activity of Otostegia fruticosa. Somaia A. Al-Madhagy, Sameh S. Gad, Eman S. Mostafa, Simone Angeloni, Muhammed A. Saad, Omar M. Sabry, Giovani Caprioli & Seham S. El-Hawary. Natural Product Research – 2022. [link]
  • Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway. El-Safty, Hala; Ismail, Ashraf; Mohsen, Rania; El-Sahar, Ayman; Saad, Muhammed A. Brain Research Bulletin, 2022, 181, pp. 109–120. [link]
  • Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats. El-Ghannam, Mohamed S.; Saad, Muhammed A.; Nassar, Noha N.; El-Yamany, Muhammad Farag; El-Bahy, Alshaymaa A.Z.. Toxicology and Applied Pharmacology, 2022, 438, 115906. [link]
  • Liraglutide Improves Cognitive and Neuronal Function in 3-NP Rat Model of Huntington’s Disease. Shawki, Samar M.; Saad, Mohammed A.; Rahmo, Rania M.; Wadie, Walaa; El-Abhar, Hanan S. Frontiers in Pharmacology, 2021, 12, 731483. [link]
  • Dismantling Parkinson’s disease with herbs: MAO-B inhibitory activity and quantification of chemical constituents using HPLC-MS/MS of Egyptian local market plants. Soha Ramadan, Manal M. Sabry, Muhammed A Saad, Simone Angeloni, Omar M. Sabry, Giovanni Caprioli & Soheir M. El Zalabani. Natural Product Research – 2021. [link]
  • Nano-Ivabradine Averts Behavioral Anomalies in Huntington’s Disease Rat Model via Modulating Rhes/m-Tor Pathway. Saad, Muhammed A.; Ahmed, Maha A.E.; Elbadawy, Norhan N.; Abdelkader, Noha F. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2021, 111, 110368. [link]
  • Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl3-induced Alzheimer-like pathology model. Saleh, Rofida A.; Eissa, Tarek F.; Abdallah, Dalaal M.; Saad, Muhammed A.; El-Abhar, Hanan S. Scientific Reports, 2021, 11(1), 12040. [link]
  • Agomelatine attenuates alcohol craving and withdrawal symptoms by modulating the Notch1 signaling pathway in rats. Doaa Fathi, Ahmed I.Abulsoud, Muhammed A.Saad, Noha N.Nassar, Mina M.Maksimos, Sherine M.Rizk, Mahmoud A.Senousy. Life Sciences – 2021. [link]
  • Vortioxetine mitigates neuronal damage by restricting PERK/eIF2α/ATF4/CHOP signaling pathway in rats subjected to focal cerebral ischemia-reperfusion. Emam, Amr M.; Saad, Muhammad A.; Ahmed, Naglaa A.; Zaki, Hala F.Life Sciences, 2021, 283, 119865. [link]
  • Bone marrow mononuclear cells boosts anti- cytogentical aberration effect of N-acetylcysteine and α-lipoic acid in rat’s liver and bone marrow: implication of oxidative and inflammatory pathways. El-Yamany, Muhammed. F.; Zaki, Eman S.; Shaltout, Sherif A.; Saad, Muhammed A. Toxicology Mechanisms and Methods, 2021, 31(6), pp. 437–449. [link]
  • Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways. Arab, Hany H.; Al-Shorbagy, Muhammad Y.; Saad, Muhammed A. Chemico-Biological Interactions, 2021, 335, 109368. [link]
  • Liraglutide mends cognitive impairment by averting Notch signaling pathway overexpression in a rat model of polycystic ovary syndrome. Saad, Muhammed A.; Eltarzy, Muhammad A.; Abdel Salam, Rania M.; Ahmed, Maha A.E. Life Sciences, 2021, 265, 118731. [link]
  • Eprosartan: A closer insight into its neuroprotective activity in rats with focal cerebral ischemia–reperfusion injury. Muhammad A. E. Saad, Mohamed I. M. Fahmy, Rabab H. Sayed, Muhammad F. El-Yamany, Reham El-Naggar, Ahmed A. E. Hegazy, Muhammad Al-Shorbagy. Journal of Biochemical and Molecular Toxicology – 2021. [link]
  • Effect Of (+) And (-) Hydroxycitric Acid Sterio-Isomers Present In Natural Products In Counteracting Insulin Resistance. hadir Farouk, Muhammed A. Saad, Sawsan S. Mahmoud, Mohammed F. El-Yamany, Ola A. Sharaf, Rania F. Ahmed, Ezz E. El-Denshary. Egyptian Journal of Chemistry – 2020, 63(11), pp. 4341–4354. [link]
  • Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways. Arab, Hany H.; Saad, Muhammed A.; El-Sahar, Ayman E.; Al-Shorbagy, Muhammad Y. Archives of Biochemistry and Biophysics, 2020, 693, 108552. [link]
  • Neuroprotective Effects of Vildagliptin on Drug Induced Alzheimer’s disease in Rats with Metabolic Syndrome: Role of Hippocampal Klotho and AKT signalling pathways. Yossef, Rasha R.; Al-Yamany, Mohamed F.; Saad, Muhammed A.; El-Sahar, Ayman E. European Journal of Pharmacology, 2020, 889, 173612. [link]
  • Dapagliflozin improves behavioral dysfunction of Huntington’s disease in rats via inhibiting apoptosis-related glycolysis. El-Sahar, Ayman E.; Rastanawi, Alyasaa A.; El-Yamany, Muhammed F.; Saad, Muhammed A. Life Sciences, 2020, 257, 118076. [link]
  • Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: The protective role of hesperidin. Hebatullah S.Helmy, Mahmoud A.Senousy, Ayman E.El-Sahar, Rabab H.Sayed, Muhammed A.Saad, Eman M.Elbaz. Toxicology – 2020. 433-434, 152406. [link]
  • Nateglinide Exerts Neuroprotective Effects via Downregulation of HIF-1α/TIM-3 Inflammatory Pathway and Promotion of Caveolin-1 Expression in the Rat’s Hippocampus Subjected to Focal Cerebral Ischemia/Reperfusion Injury. Muhammad A. Saad, Mohamed I. Fahmy, Muhammad Al-Shorbagy, Naglaa Assaf, Ahmed A. Hegazy & Muhammad F. El-Yamany. Inflammation – 2020. 43(2), pp. 401–416. [link]
  • Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington’s disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways. Elbaz, Eman M.; Helmy, Hebatullah S.; El-Sahar, Ayman E.; Saad, Muhammed A.; Sayed, Rabab H. Neurochemistry International, 2019, 131, 104548. [link]
  • Nicorandil abates arthritic perturbations induced by complete Freund’s adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway. Saad, Muhammed A; El-Sahhar, Ayman E.; Arab, Hany H.; Al-Shorbagy, Muhammad Y. Life Sciences, 2019, 218, pp. 284–291. [link]
  • Venlafaxine Mitigates Depressive-Like Behavior in Ovariectomized Rats by Activating the EPO/EPOR/JAK2 Signaling Pathway and Increasing the Serum Estradiol Level. Muhammed A. Saad, Ayman E. El-Sahar, Rabab H. Sayed, Eman M. Elbaz, Hebatullah S. Helmy & Mahmoud A. Senousy. Neurotherapeutics – 2019. 16(2), pp. 404–415. [link]
  • Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis. Saad, Muhammed A.; Rastanawi, Alyasaa A.; El-Yamany, Muhammed F. Life Sciences, 2018, 215, pp. 11–21. [link]
  • Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats. Farrag, S.M., Hamzawy, M.A., El-Yamany, M.F., Saad, M.A., Nassar, N.N. Life Sciences, 2018, 203, pp. 129–140. [link]
  • Neuroprotective Effect of Nebivolol against Cisplatin Associated Depressive-like Behavior in Rat. Abdelkader, Noha F.; Saad, Muhammed A.; Abdelsalam, Rania M. Journal of Neurochemistry, 2017, 141(3), pp. 449–460. [link]
  • Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic protein. Sayed, Rabab H.; Saad, Muhammed A.; El-Sahar, Ayman E. Toxicology and Applied Pharmacology, 2016, 311, pp. 52–60. [link]
  • Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion. Saad, Muhammed A.; Abdel Salam, Rania M.; Kenawy, Sanaa A.; Attia, Amina S. Pharmacological Reports, 2015, 67(1), pp. 115–122. [link]
  • Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist Protects Against Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rats. Saad, Muhammed A.; Abdel Salam, Rania M.; Kenawy, Sanaa A.; Attia, Amina S. Neurochemical Research, 2015, 40(1), pp. 139–150. [link]
  • Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia–reperfusion in rats. Saad, Muhammed A.; Abdel Salam, Rania M.; Kenawy, Sanaa A.; Attia, Amina S. Chemico-Biological Interactions, 2015, 232, pp. 21–29. [link]
  • Potential effects of yohimbine and sildenafil on erectile dysfunction in rats. Saad, Muhammed A.; Eid, Nihad I.; Abd El-Latif, Hekma A.; Sayed, Helmy M. European Journal of Pharmacology, 2013, 700(1-3), pp. 127–133. [link]

College of Pharmacy