Dr. Muhammad Al-Shorbagy

Gulf Medical University > Dr. Muhammad Al-Shorbagy

Associate Dean Academics and Associate Professor of Pharmacology & Toxicology

Education

  • Ph.D. from Cairo University, Egypt in 2012
  • MSc in Pharmacology and Toxicology from Cairo University, Egypt in 2008
  • B. Pharm from Cairo University, Egypt in 2000

Research Interest

  • Neuropharmacology
  • Molecular mechanisms involved in various inflammatory disorders and diabetes
  • Co-development and validation of orthogonal testing protocols for quality/safety assessment of biopharmaceuticals

Selected Publications

  • Arab, H. H., Eid, A. H., Yahia, R., Alsufyani, S. E., Ashour, A. M., El-Sheikh, A. A. K., Darwish, H. W., Saad, M. A., Al-Shorbagy, M. Y., & Masoud, M. A. (2023). Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats. Pharmaceuticals, 16(9), 1214. [link]
  • Arab, H. H., Fikry, E. M., Alsufyani, S. E., Ashour, A. M., El-Sheikh, A. A. K., Darwish, H. W., Al-Hossaini, A. M., Saad, M. A., Al-Shorbagy, M. Y., & Eid, A. H. (2023). Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways. Pharmaceuticals, 16(7), 1006. [link]
  • Saad, M.A, Eissa, N., Ahmed, M., ElMeshad, A., Laible, G., Attia, A., Al-Ghobashy, M.A., Abdelsalam, R.M., Al-Shorbagy, M.Y. (2022). Nanoformulated Recombinant Human Myelin Basic Protein and Rituximab Modulate Neuronal Perturbations in Experimental Autoimmune Encephalomyelitis in Mice. International Journal Of Nanomedicine, Volume 17, 3967-3987. doi: 10.2147/ijn.s359114. [link]
  • Saad, M., Al-Shorbagy, M., & Arab, H. (2022). Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats. Molecular Neurobiology. doi: 10.1007/s12035-022-02852-0. [link]
  • Al-Shorbagy, M.Y., Wadie, W., El-Tanbouly, D.M. (2021). Trimetazidine Modulates Mitochondrial Redox Status and Disrupted Glutamate Homeostasis in a Rat Model of Epilepsy. Front. Pharmacol. 12:735165. [link]
  • El-Sadek, H., AL-Shorbagy, M., Awny, M., Abdallah, D. and El-Abhar, H., 2021. Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-κB/HMGB-1 trajectories. Journal of Pharmacological Sciences, 146(3), pp.136-148. [link]
  • Mohammed, R.A., El-Yamany, M.F., Abdel-Rahman, A.A., Nassar, N.N., Al-Shorbagy, M.Y. Role of pERK1/2-NFκB signaling in the neuroprotective effect of Thalidomide against cerebral ischemia reperfusion injury in rats. European Journal of Pharmacology.:173872. [link]
  • Arab, H.H., Al-Shorbagy, M.Y., Saad, M.A. Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways. Chemico-Biological Interactions.:109368. [link]
  • Zaky, D. A., Abouelfadl, D. M., Nassar, N. N., Abdallah, D. M., & Al-Shorbagy, M. Y. (2020). The paradox of dipeptidyl peptidase IV inhibition in enterocytic differentiation and epithelial-mesenchymal transition in rat cholestatic sepsis. Toxicol Appl Pharmacol, 394, 114956. doi:10.1016/j.taap.2020.114956
  • Yahia, H., Hassan, A., El-Ansary, M. R., Al-Shorbagy, M. Y., & El-Yamany, M. F. (2020). IL-6/STAT3 and adipokine modulation using tocilizumab in rats with fructose-induced metabolic syndrome. Naunyn Schmiedebergs Arch Pharmacol, 393(12), 2279-2292. doi:10.1007/s00210-020-01940-z
  • Saad, M. A. E., Fahmy, M. I. M., Al-Shorbagy, M., Assaf, N., Hegazy, A. A. E., & El-Yamany, M. F. (2020). Nateglinide Exerts Neuroprotective Effects via Downregulation of HIF-1α/TIM-3 Inflammatory Pathway and Promotion of Caveolin-1 Expression in the Rat’s Hippocampus Subjected to Focal Cerebral Ischemia/Reperfusion Injury. Inflammation, 43(2), 401-416. doi:10.1007/s10753-019-01154-3
  • Arab, H. H., Saad, M. A., El-Sahar, A. E., & Al-Shorbagy, M. Y. (2020). Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways. Arch Biochem Biophys, 693, 108552. doi:10.1016/j.abb.2020.108552
  • Abdelhamid, Y. A., Elyamany, M. F., Al-Shorbagy, M. Y., & Badary, O. A. (2020). Effects of TNF-α antagonist infliximab on fructose-induced metabolic syndrome in rats. Hum Exp Toxicol, 960327120969960. doi:10.1177/0960327120969960
  • Saad, M. A., El-Sahhar, A. E., Arab, H. H., & Al-Shorbagy, M. Y. (2019). Nicorandil abates arthritic perturbations induced by complete Freund’s adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway. Life Sci, 218, 284-291. doi:10.1016/j.lfs.2019.01.002
  • Radwan, A., El-Lakkany, N. M., William, S., El-Feky, G. S., Al-Shorbagy, M. Y., Saleh, S., & Botros, S. (2019). A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection. Parasit Vectors, 12(1), 304. doi:10.1186/s13071-019-3563-z
  • Hassan, N. F., Nada, S. A., Hassan, A., El-Ansary, M. R., Al-Shorbagy, M. Y., & Abdelsalam, R. M. (2019). Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis. Inflammation, 42(3), 1056-1070. doi:10.1007/s10753-019-00967-6
  • Choucry, A. M., Al-Shorbagy, M. Y., Attia, A. S., & El-Abhar, H. S. (2019). Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats. J Mol Neurosci, 68(1), 78-90. doi:10.1007/s12031-019-01284-1
  • Ibrahim, S. M., Al-Shorbagy, M. Y., Abdallah, D. M., & El-Abhar, H. S. (2018). Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice. Sci Rep, 8(1), 16814. doi:10.1038/s41598-018-35254-1
  • Ali, R. M., Al-Shorbagy, M. Y., Helmy, M. W., & El-Abhar, H. S. (2018). Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone. Eur J Pharmacol, 831, 68-76. doi:10.1016/j.ejphar.2018.04.032
  • AbdElhameid, M. K., Labib, M. B., Negmeldin, A. T., Al-Shorbagy, M., & Mohammed, M. R. (2018). Design, synthesis, and screening of ortho-amino thiophene carboxamide derivatives on hepatocellular carcinomaas VEGFR-2Inhibitors. J Enzyme Inhib Med Chem, 33(1), 1472-1493. doi:10.1080/14756366.2018.1503654
  • Abd Elhameid, M. K., Ryad, N., Al-Shorbagy, M. Y., Mohammed, M. R., Ismail, M. M., & El Meligie, S. (2018). Design, Synthesis and Screening of 4,6-Diaryl Pyridine and Pyrimidine Derivatives as Potential Cytotoxic Molecules. Chem Pharm Bull (Tokyo), 66(10), 939-952. doi:10.1248/cpb.c18-00269
  • Salem, H. A., & Al-Shorbagy, M. Y. (2017). Evaluation of the relaxant effect of levetiracetam on isolated rat duodenum. Fundam Clin Pharmacol, 31(1), 75-82. doi:10.1111/fcp.12240
  • Aldakinah, A. A., Al-Shorbagy, M. Y., Abdallah, D. M., & El-Abhar, H. S. (2017). Trigonelline and vildagliptin antidiabetic effect: improvement of insulin signalling pathway. J Pharm Pharmacol, 69(7), 856-864. doi:10.1111/jphp.12713
  • Al-Shorbagy, M. Y., & Nassar, N. N. (2017). Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. Naunyn Schmiedebergs Arch Pharmacol, 390(1), 61-68. doi:10.1007/s00210-016-1303-x
  • Al-Ghobashy, M. A., ElMeshad, A. N., Abdelsalam, R. M., Nooh, M. M., Al-Shorbagy, M., & Laible, G. (2017). Development and Pre-Clinical Evaluation of Recombinant Human Myelin Basic Protein Nano Therapeutic Vaccine in Experimental Autoimmune Encephalomyelitis Mice Animal Model. Sci Rep, 7, 46468. doi:10.1038/srep46468
  • Abd-ElSalam, H. A., Al-Ghobashy, M. A., Al-Shorbagy, M., Nassar, N., Zaazaa, H. E., & Ibrahim, M. A. (2016). Correlation of In Vivo and In Vitro Assay Results for Assessment of Free Radical Scavenging Activity of Green Tea Nutraceuticals. J Food Sci, 81(7), C1707-1715. doi:10.1111/1750-3841.13362
  • Nassar, N. N., Al-Shorbagy, M. Y., Arab, H. H., & Abdallah, D. M. (2015). Saxagliptin: a novel antiparkinsonian approach. Neuropharmacology, 89, 308-317. doi:10.1016/j.neuropharm.2014.10.007
  • Arab, H. H., Al-Shorbagy, M. Y., Abdallah, D. M., & Nassar, N. N. (2014). Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease. PLoS One, 9(5), e97193. doi:10.1371/journal.pone.0097193
  • Al-Shorbagy, M. Y., El Sayeh, B. M., & Abdallah, D. M. (2013). Additional antiepileptic mechanisms of levetiracetam in lithium-pilocarpine treated rats. PLoS One, 8(10), e76735. doi:10.1371/journal.pone.0076735
  • Al-Shorbagy, M. Y., El Sayeh, B. M., & Abdallah, D. M. (2012). Diverse effects of variant doses of dexamethasone in lithium-pilocarpine induced seizures in rats. Can J Physiol Pharmacol, 90(1), 13-21. doi:10.1139/y11-096

College of Pharmacy