Nourhan Khaled, a dedicated student of the Master of Science in Drug Discovery and Development (MDD) program, recently had the opportunity to showcase her groundbreaking research at the 116th American Association for Cancer Research (AACR) Annual Meeting held in Orlando, Florida, USA. Nourhan’s research poster presentation titled “Statistical Optimization of Stable Quercetin Nanoparticles for Tumor Targeting” garnered significant attention at the prestigious event.
The study aimed to address the limitations of using Quercetin, a flavonoid with promising anticancer properties, in clinical settings due to its low solubility, bioavailability, and instability. The optimized nanoparticles were compared to free Quercetin powder in conditioned media obtained from HCT-116 colorectal cancer cell line subculture. The cytotoxic effects of the optimized Quercetin nanoparticles and the free drug were evaluated against HT-29 and HCT116 colorectal cancer cell lines under normoxic conditions using MTT assay. Flow cytometry and Annexin-V/FITC apoptotic assay were employed to measure apoptosis induction.
Nourhan’s research provides valuable insights into developing stable Quercetin nanoparticles for effective tumor targeting. Her work contributes to the ongoing efforts of the MDD program to advance drug discovery and development in the field of cancer research.
The College of Pharmacy and the MDD Program congratulates Nourhan Khaled for her exceptional achievements and wishes her continued success in her future endeavors.