Discovery of chemical tools and hypoxia-activated prodrugs to explore the tumor microenvironment: Research Seminar

On November 29, Dr. Klaus Pors, Senior Lecturer in Chemical Biology, School of Pharmacy and Medical Sciences (Faculty of Life Sciences), University of Bradford, UK, delivered a research seminar about utilizing the Intratumoral microenvironmental hypoxia for better and more efficient tumor targeting. Dr. Pors started his presentation by showing the unique intratumoral microenvironmental biochemical and molecular peculiarities and how to utilize this in tumor specific imaging and drug targeting. He gave many examples since the discovery of actinomycin, terapazamine and finally the recent Alchemix and duocarmycin bioprecursors.

Dr. Pors research interests lie at the interface of chemistry and biology: the development of chemical and biological tools to understand the mechanism of action and molecular target engagement of new chemotypes; targeted chemotherapy; molecular fluorescent probes to stain live cells; and molecular delivery devices.

The seminar was attended by the MSc in Drug Discovery & Development (MDD) students as part of their research seminar course.

Dean of the College of Pharmacy, Prof. Khalifa commented: Our MDD students are privileged to be engaged in discussions with world class scientists during the graduate program. Such interactions will help position them for an exciting future as successful academic scientists.