Dr. Ibrahim Elsayed

Gulf Medical University > Dr. Ibrahim Elsayed

Dean of Quality Assurance & Institutional Effectiveness
Professor of Pharmaceutical Sciences

Education

  • B.Pharm from Cairo University, Egypt in 2004
  • MSc in Pharmaceutics and Industrial Pharmacy from Cairo University, Egypt in 2008
  • Ph.D. from Cairo University, Egypt in 2011
  • Graduate Diploma in Health Profession Education from Gulf Medical University, UAE in 2015

Research Interest

  • Use of nanotechnology in drug delivery, solubilization, targeting and bioavailability enhancement

Selected Publications

  • Said, M., Elsayed, I., Aboelwafa, A. A., Elshafeey, A. H., & Hassan, M. (2024). Ocular Mucoadhesive and Biodegradable Sponge-Like Inserts for the Sustained and Controlled Delivery of Voriconazole; Preparation, D-optimal Factorial Optimization and in-vivo Evaluation. Journal of Pharmaceutical Sciences, 113(4), 961–973. [link]
  • Osman, A.L., Hussein, S.E.O., Nizam, I., Dilip, D., Mahamadou, M., Al Herafi, J., Gulroz, S., Elsayed, I., Eltom, A.E., Finney, D., Kandakurti, P.K. An in Vitro Evaluation of Anti-fungal Activity of Different Nano forms of Fluconazole Against Candida albicans. Biomed Pharmacol J 2023;16(3).
  • Adel, S., Fahmy, R. H., Elsayed, I., Mohamed, M. I., & Ibrahim, R. R. (2023). Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections. Drug delivery and translational research, 13(12), 2982–3002. [link]
  • Adel, S., Fahmy, R. H., Elsayed, I., Mohamed, M. I., & Ragaey Ibrahim, R. (2023). Exploiting Itraconazole-loaded nanomixed micelles in coated capsules as efficient colon-targeted delivery system for improved antifungal and potential anticancer efficacy. Pharmaceutical Development and Technology, 1–26. [link]
  • El-Dahmy, R.M., Elsayed, I., Hussein, J., Althubiti, M., Almaimani, R.A., El-Readi, M.Z., Elbaset, M.A., Ibrahim, B.M.M. Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and Pharmacological Evaluation. Pharmaceutics 2023, 15, 1083. [link]
  • El-Dahmy, R., Elshafeey, A., Abd El Gawad, N., El-Gazayerly, O. and Elsayed, I. 2021. Statistical optimization of nanostructured gels for enhancement of vinpocetine transnasal and transdermal permeation. Journal of Drug Delivery Science and Technology, p.102871. [link]
  • Algehani, R., Abou Khouzam, R., Hegazy, G., Alamoudi, A., El-Halawany, A., El Dine, R., Ajabnoor, G., Al-Abbasi, F., Baghdadi, M., Elsayed, I., Hattori, M. and Al-Abd, A.M. 2021. Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells. Biomedicine & Pharmacotherapy, 140, p.111730. [link]
  • Naguib, M., Elsayed, I., Teaima, M. 2021. Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride. International Journal of Nanomedicine, Volume 16, pp.2917-2931. [link]
  • Haider, M., Elsayed, I., Ahmed, I.S., Fares, A.R. In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In Vivo Evaluation. Pharmaceuticals. 2021 Jan;14(1):66. [link]
  • Elsenosy, F.M., Abdelbary, G.A., Elshafeey, A.H., Elsayed, I. and Fares, A.R., 2020. Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies. International Journal of Nanomedicine, 15, pp.9517-9537. [link]
  • Hussain, Z., Thu, H., Elsayed, I., Abourehab, M., Khan, S., Sohail, M., Sarfraz, R. and Farooq, M., 2020. Nano-scaled materials may induce severe neurotoxicity upon chronic exposure to brain tissues: A critical appraisal and recent updates on predisposing factors, underlying mechanism, and future prospects. Journal of Controlled Release. [link]
  • Said, M., Aboelwafa, A., Elshafeey, A., & Elsayed, I. (2020). Central Composite Optimization of Ocular Mucoadhesive Cubosomes for Enhanced Bioavailability and Controlled Delivery of Voriconazole. Journal Of Drug Delivery Science And Technology, 102075. doi: 10.1016/j.jddst.2020.102075. [link]
  • Joseph Naguib, M., Moustafa Kamel, A., Thabet Negmeldin, A., Elshafeey, A. H., & Elsayed, I. (2020). Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency. Drug Delivery, 27(1), 996-1009. [link]
  • Elshafeey, A., Zayed, R., Shukr, M., & Elsayed, I. (2020). Sucrose acetate isobutyrate based nanovesicles: A promising platform for drug delivery and bioavailability enhancement. Journal Of Drug Delivery Science And Technology, 101806. doi: 10.1016/j.jddst.2020.101806. [link]
  • Elsayed, I., El-Dahmy, R.M., El-Emam, S.Z. et al. Response surface optimization of biocompatible elastic nanovesicles loaded with rosuvastatin calcium: enhanced bioavailability and anticancer efficacy. Drug Deliv. and Transl. Res. (2020). [link]
  • El-Ridy MS, Yehia SA, Elsayed I, Younis MM, F. Abdel-Rahman R, El-Gamil MA. (2019) Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation. Journal of liposome research. 23:1-4. – [link]
  • Elsayed, I., El-Dahmy, R. M., Elshafeey, A. H., El Gawad, A., Abdelaziz, N., Gazayerly, E., & Naim, O. (2019). Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System. Pharmaceutics, 11(6), 275. [Link]
  • El-Ridy, M.S., Yehia S.A., Elsayed, I., Younis, M.M., Fawzy, A.R.R., & Ahmed, E.M. (2018). Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation, Journal of Liposome Research, 1-18 [Link]
  • Sayed, S., Elsayed, I., Ismail, M.M. (2018). Optimization of β-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug. International Journal of Pharmaceutics, 549(1), 249-60. [Link]
  • Said, M., Elsayed, I., Aboelwafa, A. A., & Elshafeey, A. H. (2018). A novel concept of overcoming the skin barrier using augmented liquid nanocrystals: Box-Behnken optimization, ex vivo and in vivo evaluation. Colloids and Surfaces B: Biointerfaces, 170 (1), 258-265.  [Link]
  • Afify, E. A. M. R., Elsayed, I., Gad, M. K., Mohamed, M. I., & Afify, A. E. M. R. (2018). Enhancement of pharmacokinetic and pharmacological behavior of ocular dorzolamide after factorial optimization of self-assembled nanostructures. PLoS One, 13(2), e0191415 [Link]
  • Said, M., Elsayed,I., Aboelwafa, A. A., & Elshafeey, A. H. (2017). Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability. Drug Delivery 24(1), 1159. [Link]
  • Abdelrahman, F. E., Elsayed, I., Gad, M. K., Elshafeey, A. H., & Mohamed, M. I. (2017). Response surface optimization, Ex vivo and In vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone. International Journal of Pharmaceutics, 530(1-2), 1. [Link]
  • Elsayed, I., & AbouGhaly, M. H. (2016). Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation. Expert Opinion in Drug Delivery, 13(2), 207.[Link]
  • Abdelrahman, F. E., Elsayed, I., Gad, M. K., Badr, A., & Mohamed, M. I. (2015). Investigating the cubosomal ability for transnasal brain targeting: In vitro optimization, ex vivo permeation and in vivo biodistribution. International Journal of Pharmaceutics, 490(1-2), 281. [Link]
  • Mohamed, D., Elsayed, I., Mohamed, A. F., & Yehia, S. A. (2015). Real time stability and viability prediction of the anticancer BCG after lyophilization. Drug Development and Industrial Pharmacy, 41(11), 1769.[Link]
  • Ahmed Abdelbary, A., Elsayed, I., & Hassen Elshafeey, A. (2015). Design and development of novel lipid based gastroretentive delivery system: response surface analysis, in-vivo imaging and pharmacokinetic study. Drug Delivery, 22(1), 37.[Link]
  • El-Dahmy, R. M., Elsayed, I., Elshafeey, A. H., Gawad, N. A., & El-Gazayerly, O. N. (2014). Optimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterization. International Journal of Pharmaceutics, 477(1-2), 39. [Link]
  • ElKasabgy, N. A., Elsayed, I., & Elshafeey, A. H. (2014). Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: in-vitro and in-vivo characterization. International Journal of Pharmaceutics, 472(1-2), 369. [Link]
  • Elsayed, I., Abdelbary, A. A., & Elshafeey, A. H. (2014). Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers. International Journal of Nanomedicine, 9, 2943.[Link]
  • Shamma, R. N., & Elsayed, I. (2013). Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization. Journal of Liposome Research, 23(3), 244. [Link]

College of Pharmacy