Dr. Raefa Abou Khouzam

Assistant Professor of Genetics, Molecular & Cellular Biology

Ph.D. in “Genetics, Molecular, and Cellular Biology” from the University of Pavia, Italy

dr.raefa@gmu.ac.ae

Publications:

• Abou Khouzam R, Janji B, Thiery J, Zaarour RF, Chamseddined AN, Mayre H, Savagner P, Kieda C, Gad S, Buart S, Lehn JM, Limani P, Chouaib S. “Hypoxia as a potential inducer of immune tolerance, tumor plasticity and a driver of tumor mutational burden: Impact on cancer immunotherapy”. Seminars in Cancer Biology. 2023. 97:104-123. doi: 10.1016/j.semcancer.2023.11.008
• Abou Khouzam R, Sharda M, Shyama Prasad R, Kyerewah-Kersi SM, Zeinelabdin NA, Mahmood AS, Nawafleh H, Khan MS, Venkatesh GH, Chouaib S. “Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells”. Front. Cell Dev. Biol. Sec. Cancer Cell Biology. 2023. 11:1095419. doi: 10.3389/fcell.2023.1095419.
• Abou Khouzam R, Lehn JM, Mayr H, Clavien PA, Wallace MB, Ducreux M, Limani P, Chouaib S. “Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy.” Cancers (Basel). 2023. 15:1235. doi: 10.3390/cancers15041235
• Goutham HV *, Abou Khouzam R *, Moustafa Elsayed WS, Zeinelabdin NA, Terry S, Chouaib S. “Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?” Oncoimmunology. 2021. 27: 1974233. doi: 10.1080/2162402X.2021.1974233. (*Equal contributors)
• Abou Khouzam R, Rao SP, Goutham HV, Zeinelabdin N, Buart S, Meylan M, Nimmakayalu M, Terry S, Chouaib S. “An eight-gene hypoxia signature predicts survival in pancreatic cancer and is associated with an immunosuppressed tumor microenvironment”. Frontiers in Immunology. 2021. 12: 680435. doi: 10.3389/fimmu.2021.680435